PARP1 and NAD+ metabolism

We recently collaborated with a scientific group working on epigenetics and metabolism to illustrate their work. The scientist of our company, Dr. Sarah Hurtado-Bagès, is the first author of this review from Marcus Buschbeck lab (Josep Carreras Research Institute, Spain). It was recently published in Molecular Metabolism journal.

Short legend of the figures: Poly(ADP-ribose) polymerase (PARP) family is involved in crucial cell processes, including DNA repair. PARP enzymes generate ADP-ribose post-transcriptional modifications. Among other functions, ADP-ribose levels impact whole cellular energy. ADP-ribose is generated via the hydrolysis of NAD+ through its consumption by PARP enzymes. NAD+ is a crucial cofactor involved in energy homeostasis in all cellular compartments. Massive amount of NAD+ is recycled through its salvage pathway in different cellular organelles. In cells, balance matters. For example, it is toxic for the cells when PARP enzymes over-consume NAD+. In this context, the histone variant macroH2A1.1 has been shown to inhibit | tame PARP activity to some extent and in specific condition (cell stress, cell differentiation, etc).

https://doi.org/10.1016/j.molmet.2020.01.014

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